Gene Details

ID's — ENO2 ; P09104
Alias SwissProt Name Old Accessions Ensembl Gene Description
ENOG_HUMAN B7Z2X9,Q96J33 ENSG00000111674 Gamma-enolase

Features
Chromosome location Molecular wt. (Da) Protein length
12p13.31 47269 434

Properties
Subcellular
Localization		 Enzyme ID Domain Function Disease
Cytoplasm;Cell membrane 4.2.1.11 --- Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity). {ECO:0000250}. ---

Classification of DNLCs into distinct cell subtypes (i.e. neuronal or glial)
  Neurons Oligodendrocyte
progenitor cells		 Neuron
progenitor cells		 Microglial cells
Transcript
expression count		 910 207 131 197
Average UMI count
(unique molecular identifier)		 2.41 2.14 2.47 2.06
Cell subtype Neural progenitor cells FDR(q value) 0.000127338

Mitochondrial localization
Evidence
GeneCards: 2

Complexes

Complex details — ENO2 ; P09104
Complex Id
 Number of subunits Complex members View Complex
CID003 19 IDH1, AADAT, TXNRD2, CS, GSR, TF, OAT, ENO2, GOT1, AGA, TYK2, ECHS1, PGD, OXCT1, TRAP1, ACOX1, KYAT3, CHCHD4, MCFD2  

Interactions

PPI — ENO2 ; P09104 interacts with
Protein1
 Protein2
 Gene1
 Gene2
 Is Mt
Protein1		 Is Mt
Protein2		 Celltype
Protein1		 Celltype
Protein2		 Σ LLS
DN Score		 Σ LLS
ECSC Score		 Fold Change DF
Interaction		 p-Value DF Interactions
 # Sources of supporting evidence Description1
 Description2
O75390 P09104 CS ENO2 Y Y Oligodendrocyte precursor cells Neural progenitor cells --- --- 1.6 2.073e+0 --- Citrate synthase, mitochondrial Gamma-enolase
P09104 Q8N5Z0 ENO2 AADAT Y Y Neural progenitor cells Oligodendrocyte precursor cells --- --- --- --- Y Gamma-enolase Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
P09104 Q15067 ENO2 ACOX1 Y Y Neural progenitor cells Oligodendrocyte precursor cells --- --- --- --- Y Gamma-enolase Peroxisomal acyl-coenzyme A oxidase 1 {ECO:0000303|PubMed:8117268}
P09104 Q8N4Q1 ENO2 CHCHD4 Y Y Neural progenitor cells Oligodendrocyte precursor cells --- --- 1.49 4.672e+0 --- Gamma-enolase Mitochondrial intermembrane space import and assembly protein 40
P09104 P09622 ENO2 DLD Y Y Neural progenitor cells Oligodendrocyte precursor cells --- --- 1.28 5.915e+0 --- Gamma-enolase Dihydrolipoyl dehydrogenase, mitochondrial
P09104 P30084 ENO2 ECHS1 Y Y Neural progenitor cells Neurons --- --- --- --- --- Gamma-enolase Enoyl-CoA hydratase, mitochondrial
P09104 P42126 ENO2 ECI1 Y Y Neural progenitor cells Neurons --- --- 1.45 2.896e+0 --- Gamma-enolase Enoyl-CoA delta isomerase 1, mitochondrial
P09104 P17174 ENO2 GOT1 Y Y Neural progenitor cells Oligodendrocyte precursor cells --- --- --- --- Y Gamma-enolase Aspartate aminotransferase, cytoplasmic
P09104 Q6YP21 ENO2 KYAT3 Y Y Neural progenitor cells Oligodendrocyte precursor cells --- --- --- --- Y Gamma-enolase Kynurenine--oxoglutarate transaminase 3
P09104 P55809 ENO2 OXCT1 Y Y Neural progenitor cells Oligodendrocyte precursor cells --- --- --- --- --- Gamma-enolase Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
P09104 Q12931 ENO2 TRAP1 Y Y Neural progenitor cells Oligodendrocyte precursor cells --- --- --- --- --- Gamma-enolase Heat shock protein 75 kDa, mitochondrial
P09104 Q9NNW7 ENO2 TXNRD2 Y Y Neural progenitor cells Oligodendrocyte precursor cells --- --- 1.74 4.496e+0 Y Gamma-enolase Thioredoxin reductase 2, mitochondrial
P00390 P09104 GSR ENO2 Y Y Oligodendrocyte precursor cells Neural progenitor cells --- --- 1.64 5.002e+0 Y Glutathione reductase, mitochondrial Gamma-enolase
O75874 P09104 IDH1 ENO2 Y Y --- Neural progenitor cells --- --- --- --- Y Isocitrate dehydrogenase [NADP] cytoplasmic Gamma-enolase
P04181 P09104 OAT ENO2 Y Y Oligodendrocyte precursor cells Neural progenitor cells --- --- 1.71 2.866e+0 --- Ornithine aminotransferase, mitochondrial;Ornithine aminotransferase, hepatic form;Ornithine aminotransferase, renal form Gamma-enolase
P02787 P09104 TF ENO2 Y Y --- Neural progenitor cells --- --- --- --- --- Serotransferrin Gamma-enolase