Mitochondrial  proteome Babu Lab

ID's — REXO2 ; Q9Y3B8

Alias	SwissProt Name	Old Accessions	Ensembl Gene	Description
SFN,SMFN,CGI-114	ORN_HUMAN	B2R532,Q32Q18,Q53FT1,Q6FIC6,Q9UFY7	ENSG00000076043	Oligoribonuclease, mitochondrial

Features

Chromosome location	Molecular wt. (Da)	Protein length
11q23.2	26833	237

Properties

Subcellular Localization	Enzyme ID	Domain	Function	Disease
Isoform 3: Cytoplasm	---	Exonuclease	3-to-5 exoribonuclease specific for small oligoribonucleotides. Active on small (primarily	---

Classification of DNLCs into distinct cell subtypes (i.e. neuronal or glial)

	Neurons	Oligodendrocyte progenitor cells	Neuron progenitor cells	Microglial cells
Transcript expression count	1338	332	144	208
Average UMI count (unique molecular identifier)	3.9	3.42	3.01	3.42
Cell subtype	Neurons	FDR(q value)	4.34734E-39

Mitochondrial localization

Evidence
MitoCarta v2.0|GO|GeneCards: 5|PMID: 23371551

Complex details — REXO2 ; Q9Y3B8

Complex Id	Number of subunits	Complex members	View Complex
CID007	13	HTRA2, SOD2, NFU1, REXO2, CUTA, CS, DLD, MDH1, ECI1, SUCLG1, PITRM1, ABHD10, SUCLA2

PPI — REXO2 ; Q9Y3B8 interacts with

Protein1	Protein2	Gene1	Gene2	Is Mt Protein1	Is Mt Protein2	Celltype Protein1	Celltype Protein2	Σ LLS DN Score	Σ LLS ECSC Score	Fold Change DF Interaction	p-Value DF Interactions	# Sources of supporting evidence	Description1	Description2
Q9NUJ1	Q9Y3B8	ABHD10	REXO2	Y	Y	Oligodendrocyte precursor cells	Neurons	---	---	---	---	Y	Mycophenolic acid acyl-glucuronide esterase, mitochondrial	Oligoribonuclease, mitochondrial
O75390	Q9Y3B8	CS	REXO2	Y	Y	Oligodendrocyte precursor cells	Neurons	---	---	---	---	Y	Citrate synthase, mitochondrial	Oligoribonuclease, mitochondrial
O60888	Q9Y3B8	CUTA	REXO2	Y	Y	Neurons	Neurons	---	---	---	---	Y	Protein CutA	Oligoribonuclease, mitochondrial
P09622	Q9Y3B8	DLD	REXO2	Y	Y	Oligodendrocyte precursor cells	Neurons	---	---	---	---	Y	Dihydrolipoyl dehydrogenase, mitochondrial	Oligoribonuclease, mitochondrial
Q9H3Z4	Q9Y3B8	DNAJC5	REXO2	Y	Y	Oligodendrocyte precursor cells	Neurons	---	---	---	---	Y	DnaJ homolog subfamily C member 5 {ECO:0000305}	Oligoribonuclease, mitochondrial
P42126	Q9Y3B8	ECI1	REXO2	Y	Y	Neurons	Neurons	---	---	---	---	Y	Enoyl-CoA delta isomerase 1, mitochondrial	Oligoribonuclease, mitochondrial
Q01581	Q9Y3B8	HMGCS1	REXO2	Y	Y	Oligodendrocyte precursor cells	Neurons	---	---	---	---	---	Hydroxymethylglutaryl-CoA synthase, cytoplasmic	Oligoribonuclease, mitochondrial
O43464	Q9Y3B8	HTRA2	REXO2	Y	Y	Oligodendrocyte precursor cells	Neurons	---	---	---	---	Y	Serine protease HTRA2, mitochondrial	Oligoribonuclease, mitochondrial
P40925	Q9Y3B8	MDH1	REXO2	Y	Y	Neurons	Neurons	---	---	---	---	Y	Malate dehydrogenase, cytoplasmic	Oligoribonuclease, mitochondrial
Q8NCW5	Q9Y3B8	NAXE	REXO2	Y	Y	Neurons	Neurons	---	---	1.37	3.318e+0	---	NAD(P)H-hydrate epimerase {ECO:0000255|HAMAP-Rule:MF_03159}	Oligoribonuclease, mitochondrial
Q9UMS0	Q9Y3B8	NFU1	REXO2	Y	Y	Neurons	Neurons	---	---	---	---	Y	NFU1 iron-sulfur cluster scaffold homolog, mitochondrial	Oligoribonuclease, mitochondrial
P04181	Q9Y3B8	OAT	REXO2	Y	Y	Oligodendrocyte precursor cells	Neurons	---	---	1.36	-2.315e+0	Y	Ornithine aminotransferase, mitochondrial;Ornithine aminotransferase, hepatic form;Ornithine aminotransferase, renal form	Oligoribonuclease, mitochondrial
Q5JRX3	Q9Y3B8	PITRM1	REXO2	Y	Y	Oligodendrocyte precursor cells	Neurons	---	---	---	---	Y	Presequence protease, mitochondrial	Oligoribonuclease, mitochondrial
O75439	Q9Y3B8	PMPCB	REXO2	Y	Y	Neurons	Neurons	---	---	1.36	2.058e+0	---	Mitochondrial-processing peptidase subunit beta	Oligoribonuclease, mitochondrial
P04179	Q9Y3B8	SOD2	REXO2	Y	Y	---	Neurons	---	---	1.77	4.420e+0	Y	Superoxide dismutase [Mn], mitochondrial	Oligoribonuclease, mitochondrial
Q9P2R7	Q9Y3B8	SUCLA2	REXO2	Y	Y	Oligodendrocyte precursor cells	Neurons	---	---	---	---	Y	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03220}	Oligoribonuclease, mitochondrial
P53597	Q9Y3B8	SUCLG1	REXO2	Y	Y	Neurons	Neurons	---	---	1.58	4.427e+0	Y	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03222}	Oligoribonuclease, mitochondrial
P43897	Q9Y3B8	TSFM	REXO2	Y	Y	Oligodendrocyte precursor cells	Neurons	---	1.63	---	---	Y	Elongation factor Ts, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03135}	Oligoribonuclease, mitochondrial
P31946	Q9Y3B8	YWHAB	REXO2	Y	Y	Neurons	Neurons	---	---	---	---	---	14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed	Oligoribonuclease, mitochondrial